1 Design, Construction and Characterization of Stimuli (redox potential, pH, light…) Responsive Polymeric Gene/Drug Delivery Systems; 
2 Development of Nanomaterials for tumor diagnostic and therapeutic applications; 
3 Development of Novel Biomaterials for Tissue Engineering.

硕士生每年一名

0703Z2-生物无机化学
070305-高分子化学与物理
0703J1-纳米科学与技术

生物医用高分子，纳米材料，生物材料
抗肿瘤治疗，基因治疗

2001-09--2007-06   武汉大学   理学博士
1997-09--2001-06   武汉大学   理学学士

   

Ph.D

 

   

2013-02~现在, 中国科学院高能物理研究所, 副研究员
2012-02~2013-01,University of Manitoba, 助理研究员
2009-02~2012-01,University of Manitoba, 博士后
2007-09~2008-11,Wayne State University, 博士后

   

   

   

（1） 中科院青年创新促进会, 特等奖, 部委级, 2015

（ 1 ） Multifunctional nanoparticle for doxorubicin enhanced intracellular delivery, 发明, 2012, 第 1 作者, 专利号: 61/586,833
（ 2 ） 阿霉素前药及其制备方法和可注射的组合物, 实用新型, 2013, 第 1 作者, 专利号: CN103381273-A
（ 3 ） 一种两亲性聚合物以及由其形成的磁性胶束纳米载体和其用途, 发明, 2018, 第 1 作者, 专利号: ZL201610819749.8
（ 4 ） 一种聚乙二醇/聚酰胺胺共聚物、其制备方法及包含该共聚物的两亲性siRNA载体, 发明, 2019, 第 1 作者, 专利号: ZL201610817502.2
（ 5 ） 一种粒径可控的阿霉素纳米颗粒及其制备方法, 发明, 2019, 第 1 作者, 专利号: ZL201610819358.6

   

（1） A thermoresponsive nanocarrier for mitochondria-targeted drug delivery., Chem Commun, 2019, 通讯作者
（2） Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics., Acs Appl. Mater. Interfaces,, 2019, 第 3 作者
（3） Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration,, Nano Letters, 2019, 通讯作者
（4） AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes,, Metallomics, 2019, 通讯作者
（5） Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells,, ACS Appl. Bio Mater., 2019, 通讯作者
（6） In vivo evaluation of near-infrared mediated nanoplatforms for targeted chemo-photothermal therapy and photothermo-immunotherapy,, Nanomedicine: Nanotechnology, Biology, and Medicine,, 2018, 通讯作者
（7） Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology, Nano Letters, 2018, 第 8 作者
（8） Near Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin, Acs Biomater Sci Eng,, 2018, 通讯作者
（9） pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells,, Nanomaterials, 2018, 通讯作者
（10） 帕金森病中的关键金属元素, Neurotoxicity of Key Metals in Parkinson’s Disease, 化学进展（Progress in Chemistry）, 2018, 第 2 作者
（11） Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering, Adv. Funct. Mater., 2018, 第 3 作者
（12） Iron-induced generation of mitochondrial ROS depends on AMPK activity, Biometals, 2017, 第 2 作者
（13） Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells, Biometals, 2017, 第 2 作者
（14） Mitochondria-targeted nanocarriers using hyperbranched polycations wrapped carbon nanotubes for augment photodynamic therapeutic effects, J Control Release, 2017, 通讯作者
（15） A facile construction of pH-sensitive shell-sheddable supramolecular nanoassembly codelivery anticancer drugs to combat drug resistance, J Control Release, 2017, 通讯作者
（16） In vivo chemo/photothermal therapy using near-infrared light triggered switchable nanoparticles against subcutaneous and orthotopic superficial bladder cancer, J Control Release, 2017, 通讯作者
（17） Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS, Biometals, 2017, 第 2 作者
（18） Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer, Acs Biomater Sci Eng,, 2017, 通讯作者
（19） Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects, Biomater. Sci., 2017, 通讯作者
（20） The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery., Curr. Top. Med. Chem., 2017, 通讯作者
（21） mTOR Signaling in Parkinson's Disease, Neuromolecular Med., 2017, 第 2 作者
（22） Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS, Biometals, 2017, 第 2 作者
（23） AMPK Inhibition Enhances the Neurotoxicity of Cu(II) in SH-SY5Y Cells., Neurotox. Res., 2016, 第 3 作者
（24） The Neurotoxicity of Iron, Copper and Cobalt in Parkinson’s Disease Through ROS-Mediated Mechanisms., Biometals, 2016, 第 2 作者
（25） Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-Drug Interactions., Curr. Org. Chem., 2016, 第 2 作者
（26） A thiol fluorescent probe reveals the intricate modulation of cysteine's reactivity by Cu(II), Talanta, 2016, 第 3 作者
（27） High-Throughput Screening of Substrate Specificity for Protein Tyrosine Phosphatases (PTPs) on Phosphopeptide Microarrays, Methods Mol. Biol., 2016, 第 3 作者
（28） Reduction sensitive micellar magnetic nanoparticles for cancer targeted chemotherapy, Nanomed.-Nanotechnol. Biol. Med., 2016, 通讯作者
（29） Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery, ACS Appl. Mater. Interfaces, 2016, 第 4 作者
（30） Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy, ACS Appl. Mater. Interfaces, 2016, 通讯作者
（31） Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle, Acta Biomater., 2015, 通讯作者
（32） Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand, Metallomics, 2015, 第 3 作者
（33） A Facile Strategy for In Situ Controlled Delivery of Doxorubicin with a pH-Sensitive Injectable Hydrogel, Nano Life, 2014, 通讯作者
（34） Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery, Biomaterials, 2014, 第 1 作者
（35）  Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues, Advanced Functional Materials, 2014, 第 1 作者
（36）  Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function, Scientific Reports, 2014, 第 1 作者
（37） A PNIPAAm-based thermosensitive hydrogel containing SWCNTs for stem cell transplantation in myocardial repair, Biomaterials, 2014, 第 4 作者
（38） Photo-cross-linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery, ACS Appl. Mater. Interfaces, 2013, 第 1 作者
（39） Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations, Biomaterials, 2013, 第 4 作者
（40） Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin, J. Mater. Chem., 2012, 第 1 作者
（41） pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery, Biomacromolecules, 2012, 第 1 作者
（42） Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes, European Journal of Pharmaceutical Sciences, 2012, 第 3 作者
（43） Multifunctional Nanofibrous Scaffolds Based on Poly(L-lactic acid) and Poly(L-lactic acid)-Poly(ethylene glycol) for Tissue Engineering, International Journal of Nanomedicine, 2011, 第 1 作者
（44） Degradable micelles based on hydrolytically degradable amphiphilic graft copolymers for doxorubicin delivery, Polymer, 2011, 第 1 作者
（45） Novel Poly(amidoamine)s with Pendant Primary Amines as Highly Efficient Gene Delivery Vectors, Macromolecular Bioscience, 2010, 第 2 作者
（46） Bioreducible hyperbranched poly(amido amine)s for gene delivery, Biomacromolecules, 2009, 第 1 作者
（47） Poly(beta-aminoester)s with pendant primary amines for efficient gene delivery, Bioconjugate Chemistry, 2009, 第 2 作者
（48） Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations, Molecular Therapy, 2009, 第 2 作者
（49） Effect of Nucleic Acid Size on Physical Properties and Biological Activity of Redox-Responsive Polyplexes: Plasmid DNA vs. Antisense Oligonucleotides, Molecular Therapy, 2009, 第 3 作者
（50） A cleavable-polycation template method for the fabrication of noncrosslinked, porous polyelectrolyte multilayered films, Advanced Materials, 2007, 第 1 作者
（51） Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions, Small, 2007, 第 1 作者
（52） Synthesis and degradation of poly(beta-aminoester) with pendant primary amine, Polymer, 2007, 第 1 作者

   

   

（ 1 ） 用于癌症诊断治疗的纳米载体的研究, 主持, 市地级, 2013-02--2016-01
（ 2 ） 近红外光敏多功能纳米载体的构建及药物靶向传递和成像研究, 主持, 国家级, 2014-01--2016-12
（ 3 ） 肝癌早期诊断用新型纳米材料的设计和构筑, 参与, 国家级, 2012-09--2015-08
（ 4 ） 基于胞内多种生物活性分子同时识别的荧光探针研究, 参与, 国家级, 2014-01--2018-12
（ 5 ） 中国科学院青年创新促进会, 主持, 部委级, 2015-01--2018-12
（ 6 ） 多重刺激响应性纳米药物的光热治疗与化疗的协同抗肿瘤研究, 主持, 国家级, 2016-01--2019-12

（1）光热/化疗联合免疫治疗纳米复合药物的抗肿瘤研究   2017 中国生物材料大会   2017-10-27
（2）Near-Infrared Guided Switchable Nanoparticles for Enhanced Targeted Therapy againstSubcutaneous and Orthotopic Bladder Cancer   美国材料学会2016秋季年会（Materials Research Society 2016 Fall Meeting）   2016-11-27
（3）In Vivo Evaluation of Near-Infrared Mediated Nanoplatforms for Targeted Chemo-Photothermal Therapy and Photothermo-Immunotherapy   第二届国际纳米药物大会   2016-10-18
（4）独立细胞膜片与层层组装细胞外基质制备仿生组织   2015 中国生物材料大会暨中美生物材料学会第三次专题论坛   2015-11-19
（5）还原降解性聚阳离子的细胞毒性的机理研究   中国毒理学会第七次全国毒理学大会   2015-10-25
（6）光致尺寸变换型纳米载体用于膀胱癌的靶向热化疗研究   2015年全国高分子学术论文报告会   2015-10-17
（7）Photothermally Size-Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    中国化学会第十五届胶体与界面化学会议   2015-07-17
（8）Photothermally Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    第10届中美纳米论坛   Ying Bi, Hui Gao, Yi Hu, Jun Chen,*   2015-06-26
（9）Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    2015年美国生物材料学会年会（2015 Annual Meeting of Society for Biomaterials）   Ying Bi, Hui Gao, Aiping Lan, Yi Hu, Jun Chen*   2015-04-19
（10）Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues   第五届中欧生物材料大会   Peng Chen, Ying Bi, Xiaozhong Qiu, Yi Hu, Malcolm M. Q. Xing, Jun Chen*   2015-04-14
（11）Redution Sensitive Micellar Magnatic Nanoparticles for Cancer Targeted Chemotherapy   2015年纳米药物与纳米生物技术国际会议   Hui Zhou, Ying Bi, Jun Chen*, Yi Hu   2015-04-13
（12）Near-infrared light remote-enhanced tumor targeting chemo-photothermal co-therapy using thermo/pH sensitive nanovehicle   2015转化纳米医学国际学术研讨会   Ying Bi, Yi Hu*, Yuliang Zhao, Jimin Gao, Jun Chen*   2015-01-12
（13）同步辐射技术检测甲基汞在水稻中的转运   2014年北京同步辐射装置用户学术年会暨专家会   赵甲亭，陈俊，胡毅，高愈希    2014-08-12
（14）Preparation of Biocompatible Conductive Nanomaterials for Improving Myocardial Repair   2014年国际高分子化学学术研讨会   Ying Bi, Xiaohan Xu, Yanping Qin, Hui Zhou, Yi Hu, Jun Chen,   2014-06-04
（15）Controlled release of Doxorubicin from pH and reducing agents dual responsive PEG-Reducible Poly(beta-amino ester)s-PEG micelles   239届美国化学学会年会   Jun Chen, Shufei Zhou and Wen Zhong   2010-05-20
（16）Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations   20届美国基因治疗学会年会   Chao Wu, Jun Chen, Jing Li, David Oupicky   2009-05-27
（17）Synthesis and characterization of hyperbranched poly(amido amine)s for gene delivery   第35届美国控制释放学会年会   Ye-Zi You, Jun Chen, Devika S Manickam, Qing-Hui Zhou, Lei Wan, Guangzhao Mao and David Oupicky   2008-07-12
（18）聚酯-胺阳离子/质粒DNA 多层膜的构建及其控制释放DNA   2005 全国高分子学术论文报告会   陈俊，黄世文，林文海，卓仁禧   2005-10-18

动物体内实验合作单位：

温州医科大学检验医学院 高基民 教授
哈尔滨医科大学第一附属医院 刘宏宇 院长
天津医科大学 张宁教授
南方医科大学 欧阳均 教授


材料实验合作单位：

中国科学院大学材料科学与光电技术学院 黄辉 教授
美国德州农工大学化学系 方磊 助理教授
中国科学院宁波材料技术与工程研究所 黄又举 副研究员

   

现指导学生

周梦雪  博士研究生  070301-无机化学