科院考研推荐链接:
研究领域
招生信息
招生专业
招生方向
蛋白质结构、功能与创新药物
教育背景
1979-07--1982-07 中国科学院生物物理研究所 硕士
1973-06--1977-06 中国科技大学 本科
学历
学位
工作经历
工作简历
2003-03~2007-03,中国科学院生物物理研究所, 所长
1996-07~现在, 清华大学, 教授
1992-07~1996-07,牛津大学, 高级研究员
1989-07~1992-07,英国牛津大学, 博士后
1982-07~1985-07,中国科学院生物物理研究所, 助理研究员
1977-07~1979-07,中国科学院生物物理研究所, 助理研究员
社会兼职
2010-01-01-今,Protein & Cell, 主编
2006-01-01-今,中国生物物理学会, 理事长
教授课程
专利与奖励
奖励信息
(2) 谈家桢生命科学成就奖, 特等奖, 国家级, 2008
(3) 第三世界科学院最高奖-第里雅斯特科学奖, 特等奖, 其他, 2006
(4) 何梁何利奖, 一等奖, 国家级, 2003
(5) 长江学者特聘教授, 特等奖, 部委级, 2000
(6) 求是杰出青年学者奖, 一等奖, 国家级, 1999
专利成果
出版信息
发表论文
(2) TIM-1 acts a dual-attachment receptor for Ebolavirus by interacting directly with viral GP and the PS on the viral envelope., Protein Cell., 2015, 通讯作者
(3) A novel function of the human oncogene Stil: Regulation of PC12 cell toxic susceptibility through the Shh pathway., Sci Rep., 2015, 通讯作者
(4) Tuthill TJ, Stuart DI. Structure of Ljungan virus provides insight into genome packaging of this picornavirus., Nat Commun, 2015, 通讯作者
(5) Structure Elucidation of Coxsackievirus A16 in Complex with GPP3 Informs a Systematic Review of Highly Potent Capsid Binders to Enteroviruses., PLoS Pathog., 2015, 通讯作者
(6) Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity., J Virol., 2015, 通讯作者
(7) Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion., J Cell Biol., 2015, 通讯作者
(8) Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex., Proc Natl Acad Sci U S A., 2015, 通讯作者
(9) A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface., PLoS Pathog., 2015, 通讯作者
(10) Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors., Protein Cell., 2015, 通讯作者
(11) Structural views of quinone oxidoreductase from Mycobacterium tuberculosis reveal large conformational changes induced by cofactor., FEBS J., 2015, 通讯作者
(12) Insight into the Ebola virus nucleocapsid assembly mechanism: crystal structure of Ebola virus nucleoprotein core domain at 1.8 Å resolution., Protein Cell., 2015, 通讯作者
(13) Prediction of host - pathogen protein interactions between Mycobacterium tuberculosis and Homo sapiens using sequence motifs., BMC Bioinformatics., 2015, 通讯作者
(14) A peptidyl aldehyde NK-1.8k suppresses EV71 and EV68 infection by targeting at 3Cpro., Antimicrob Agents Chemother., 2015, 通讯作者
(15) The structure of hepatitis A virus and the origins of picornaviruses., Nature, 2014, 通讯作者
(16) Structure of the nisin leader peptidase NisP revealing a C-terminal autocleavage activity. , Acta Crystallogr D Biol Crystallogr., 2014, 通讯作者
(17) More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules., Nat Struct Mol Biol, 2014, 通讯作者
(18) Current progress in antiviral strategies., Trends Pharmacol Sci. , 2014, 通讯作者
(19) Suramin inhibits EV71 infection. , Antiviral Res., 2014, 通讯作者
(20) Structural analysis of Mycobacterium tuberculosis ATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine. , FEBS J. , 2013, 通讯作者
(21) Crystal structure of Junin virus nucleoprotein., J Gen Virol. , 2013, 通讯作者
(22) Picornavirus uncoating intermediate captured in atomic detail., Nat Commun. , 2013, 通讯作者
(23) Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain. , Curr Opin Struct Biol. , 2013, 通讯作者
(24) Structural study of MCPIP1 N-terminal conserved domain reveals a PIN-like RNase., Nucleic Acids Res, 2012, 通讯作者
(25) A sensor adaptor mechanism for enterovirus uncoating from structures of EV71., Nature Structural Molecular Biology, 2012, 通讯作者
(26) Crimean-Congo hemorrhagic fever virus nucleoprotein reveals an endonuclease activity in the Bunyaviruses., Proc. Natl. Acad. Sci. USA, 2012, 通讯作者
(27) Structure-Functional Analyses of CRHSP-24 Plasticity and Dynamics in Oxidative Stress Response. , J Biol Chem., 2011, 通讯作者
(28) Structural Analysis of CYP101C1 from Novosphingobium aromaticivorans DSM12444. , Chembiochem., 2011, 通讯作者
(29) The structure of CYP101D2 unveils a potential path for substrate entry into the active site. , Biochem J. , 2011, 通讯作者
(30) ., A structural view of the antibiotic degradation enzyme NDM-1 from a superbug., Protein Cell, 2011, 通讯作者
(31) PDlim2 Selectively Interacts with the PDZ Binding Motif of Highly Pathogenic Avian H5N1 Influenza A Virus NS1., PLoS One, 2011, 通讯作者
(32) Structure, electronic properties and catalytic behaviour of an activity-enhancing CYP102A1 (P450(BM3)) variant., Dalton Trans, 2011, 通讯作者
(33) Structural study of the Cdc25 domain from Ral-specific guanine-nucleotide exchange factor RalGPS1a., Protein Cell., 2011, 通讯作者
(34) Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection., J Biol Chem, 2011, 通讯作者
(35) A strong start, a promising future., Protein Cell, 2011, 通讯作者
(36) Crystal structure of 4-diphosphocytidyl-2-C-methyl-D- erythritol kinase (IspE) from Mycobacterium tuberculosis., FASEB J. , 2011, 通讯作者
发表著作
科研活动
科研项目
( 2 ) 生物治疗协同创新中心, 主持, 研究所(学校), 2014-01--2018-12
( 3 ) 生物超大分子复合体的结构、功能与调控, 主持, 部委级, 2014-01--2018-12
参与会议
(2)Molecular Mechanism of entry of hand-foot and mouth disease (HFMD) virus 第一届世界医学峰会 2015-07-07
(3)Structural insights into the agents of hand, foot and mouth disease 亚洲生物物理大会 2015-05-08
(4)Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71 2015免疫学国际研讨会 2015-04-24
(5)Structural insights into the agents of hand, foot and mouth disease 2015-04-09
(6)Molecular Mechanism of entry of hand-foot and mouth disease (HFMD) virus 2015亚太地区肿瘤生物学和医学学术会议大会 2015-03-20
(7)我国结构生物学发展现状对同步辐射蛋白质线站建设的思考 上海光源用户年会 饶子和 2009-11-29
合作情况
项目协作单位
指导学生
已指导学生
曹晟 01 19184
孙蕾 01 19184
陈佳 01 19183
霍霞 01 19183
张文池 01 19183
章文正 01 19183
欧先金 01 19183
刘艺锦 01 19183
王岚峰 01 19183
刘学琦 01 19183
辛亮 01 19183
魏世喜 02 19183
侯海 01 19183
彭伟 01 19183
傅晟 01 19183
黄博 01 19183
童晓航 01 19183
陈瑜涛 01 19183
李爽 01 19183
周小红 01 19183
马艳林 01 19183
李元元 01 19183
吴洋 01 19183
孙玉娜 01 19183
徐继伟 01 19183
郝宁 01 19182
王璐 01 19183
李俊 01 19183
杨清竹 01 19184
官小涛 01 19183
王祥喜 01 19183
王亚鑫 01 19183
孙瑶 01 19184
董宇 01 19184
现指导学生
党明浩 01 19183
杨扬 01 19183
冉亚军 02 19183
杨盼 02 19183
王辰龙 02 19183
邱肖迪 01 19183
袁帅 01 19183
杨晓琳 02 19183
王满福 02 19183
任洁 02 19183
高海龙 02 19183
王佳灵 02 19182
王暑辉 01 19183
张兵 01 19183
钱盈 01 19183
严川强 01 19183
冯瑞 02 19183
高若谷 02 19183
冀文欣 02 19183
王男 02 19183