大连化学物理研究所 秦洪强 男
作者:科大科院考研网 发表时间:2020-03-31 来源:研招办
科院考研推荐链接:
研究领域
蛋白质翻译后修饰方法研究
蛋白质糖基化及其在转化医学中的应用
新型蛋白质结构活性探针反应研究
蛋白质氧化与疾病关联性研究
招生信息
有机化学、应用化学、化学生物学背景
招生专业
070302-分析化学
招生方向
蛋白质糖基化,蛋白-蛋白相互作用及蛋白质分泌组学
教育背景
2007-09--2013-07 中国科学院大连化学物理研究所 理学博士
2003-09--2007-07 天津大学 理学学士
2003-09--2007-07 天津大学 理学学士
学历
学位
工作经历
2013.07-2018.06 中国科学院大连化学物理研究所 副研究员
2018.07--- 中国科学院大连化学物理研究所 研究员
社会兼职
教授课程
专利与奖励
奖励信息
专利成果
( 1 ) 一种功能化修饰纳米介孔材料在蛋白质糖基化分析中的应用, 发明, 2015, 第 2 作者, 专利号: 201510534807.8
( 2 ) 一种高通量富集和鉴定内源性NO-连接糖肽的方法, 发明, 2017, 第 2 作者, 专利号: 201711180038.1
( 3 ) 一种基于拟多级谱策略的N-连接糖肽鉴定与定量分析方法, 发明, 2017, 第 2 作者, 专利号: 201711180038.1
( 2 ) 一种高通量富集和鉴定内源性NO-连接糖肽的方法, 发明, 2017, 第 2 作者, 专利号: 201711180038.1
( 3 ) 一种基于拟多级谱策略的N-连接糖肽鉴定与定量分析方法, 发明, 2017, 第 2 作者, 专利号: 201711180038.1
出版信息
发表论文
(1) A New Searching Strategy for the Identification of O-Linked Glycopeptides, Analytical Chemistry, 2019, 第 3 作者
(2) Proteomics Analysis of Site-specific Glycoforms by a Virtual Multistage Mass Spectrometry Metho, Analytica Chimica Acta, 2019, 第 1 作者
(3) LCN1 is highly expressed in cholangiocarcinoma patients and indicates poor prognosis, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 第 4 作者
(4) Highly Efficient Identification of O-GalNAc Glycosylation by an Acid-Assisted Glycoform Simplification Approach, Proteomics, 2018, 第 1 作者
(5) Recent advances in methods for the analysis of protein o-glycosylation at proteome level, JOURNAL OF SEPARATION SCIENCE, 2018, 第 2 作者
(6) Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action, CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 第 3 作者
(7) In-Depth Analysis of Glycoprotein Sialylation in Serum Using a Dual-Functional Material with Superior Hydrophilicity and Switchable Surface Charge, ANALYTICAL CHEMISTRY, 2017, 第 1 作者
(8) Proteomics Analysis of O-GaINAc Glycosylation in Human Serum by an Integrated Strategy, ANALYTICAL CHEMISTRY, 2017, 第 1 作者
(9) Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer, ONCOTARGET, 2016, 第 1 作者
(10) Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1 beta Producing Inflammasome, ACS Nano,, 2014, 第 3 作者
(11) Layer-by-layer assembly of multilayer polysaccharide coated magnetic nanoparticles for the selective enrichment of glycopeptides,, Chem. Commun., 2013, 第 2 作者
(12) Facile synthesis of yolk-shell magnetic mesoporous carbon microspheres for efficient enrichment of low abundance peptides, Nanoscale, 2013, 第 2 作者
(13) Facile preparation of ordered mesoporous silica-carbon composite nanoparticles for glycan enrichment, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
(14) Phosphoric acid functionalized mesoporous organo-silica (EPO) as the adsorbent for in situ enrichment and isotope labeling of endogenous phosphopeptides, Chem. Commun., 2012, 第 1 作者
(15) Isobaric cross-sequence labeling of peptides by using site-selective N-terminus dimethylation, Chem. Commun., 2012, 第 1 作者
(16) A poly(ethylene glycol)-brush decorated magnetic polymer for highly specific enrichment of phosphopeptides, Chem. Sci, 2012, 第 2 作者
(17) Highly Efficient Extraction of Serum Peptides by Ordered Mesoporous Carbon, Angew. Chem. Int. Ed., 2011, 第 1 作者
(18) Size-Selective Enrichment of N-Linked Glycans Using Highly Ordered Mesoporous Carbon Material and Detection by MALDI-TOF MS, Anal. Chem., 2011, 第 1 作者
(2) Proteomics Analysis of Site-specific Glycoforms by a Virtual Multistage Mass Spectrometry Metho, Analytica Chimica Acta, 2019, 第 1 作者
(3) LCN1 is highly expressed in cholangiocarcinoma patients and indicates poor prognosis, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2018, 第 4 作者
(4) Highly Efficient Identification of O-GalNAc Glycosylation by an Acid-Assisted Glycoform Simplification Approach, Proteomics, 2018, 第 1 作者
(5) Recent advances in methods for the analysis of protein o-glycosylation at proteome level, JOURNAL OF SEPARATION SCIENCE, 2018, 第 2 作者
(6) Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action, CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 第 3 作者
(7) In-Depth Analysis of Glycoprotein Sialylation in Serum Using a Dual-Functional Material with Superior Hydrophilicity and Switchable Surface Charge, ANALYTICAL CHEMISTRY, 2017, 第 1 作者
(8) Proteomics Analysis of O-GaINAc Glycosylation in Human Serum by an Integrated Strategy, ANALYTICAL CHEMISTRY, 2017, 第 1 作者
(9) Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer, ONCOTARGET, 2016, 第 1 作者
(10) Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1 beta Producing Inflammasome, ACS Nano,, 2014, 第 3 作者
(11) Layer-by-layer assembly of multilayer polysaccharide coated magnetic nanoparticles for the selective enrichment of glycopeptides,, Chem. Commun., 2013, 第 2 作者
(12) Facile synthesis of yolk-shell magnetic mesoporous carbon microspheres for efficient enrichment of low abundance peptides, Nanoscale, 2013, 第 2 作者
(13) Facile preparation of ordered mesoporous silica-carbon composite nanoparticles for glycan enrichment, CHEMICAL COMMUNICATIONS, 2013, 第 1 作者
(14) Phosphoric acid functionalized mesoporous organo-silica (EPO) as the adsorbent for in situ enrichment and isotope labeling of endogenous phosphopeptides, Chem. Commun., 2012, 第 1 作者
(15) Isobaric cross-sequence labeling of peptides by using site-selective N-terminus dimethylation, Chem. Commun., 2012, 第 1 作者
(16) A poly(ethylene glycol)-brush decorated magnetic polymer for highly specific enrichment of phosphopeptides, Chem. Sci, 2012, 第 2 作者
(17) Highly Efficient Extraction of Serum Peptides by Ordered Mesoporous Carbon, Angew. Chem. Int. Ed., 2011, 第 1 作者
(18) Size-Selective Enrichment of N-Linked Glycans Using Highly Ordered Mesoporous Carbon Material and Detection by MALDI-TOF MS, Anal. Chem., 2011, 第 1 作者
发表著作
科研活动
科研项目
( 1 ) 血清内源性多肽定量分析方法的建立及其用于抑郁症疾病标记物的筛, 主持, 国家级, 2015-01--2017-12
( 2 ) 蛋白糖基化修饰在胃癌多药耐药中特征性改变及其作用机制研究, 主持, 国家级, 2015-01--2018-12
( 3 ) 基于非天然糖代谢标记的分泌蛋白质糖基化精细分析新方法研究, 主持, 国家级, 2018-01--2021-12
( 2 ) 蛋白糖基化修饰在胃癌多药耐药中特征性改变及其作用机制研究, 主持, 国家级, 2015-01--2018-12
( 3 ) 基于非天然糖代谢标记的分泌蛋白质糖基化精细分析新方法研究, 主持, 国家级, 2018-01--2021-12
参与会议
合作情况
第四军医大学、大连医科大学、大连理工大学等单位
项目协作单位