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生命科学学院 马润林 男 博导
 

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研究领域

本研究组研究领域为免疫功能基因组学与免疫遗传学。主要研究人类免疫与自身免疫性疾病的动物模型与组胺过敏相关基因的功能;反刍类动物免疫基因组MHC结构与功能的关系以及MHC比较进化;肺器官早期发育与免疫;侵染性及自身免疫性疾病的致病致癌分子机理。

 

招生信息

   
招生专业
071007-遗传学
085238-生物工程
071008-发育生物学
招生方向
分子遗传学
免疫遗传学
遗传与进化

教育背景

1987-09--1991-08   堪萨斯州立大学   博士
1985-09--1987-08   美国明尼苏达大学   硕士
1978-09--1982-08   石河子大学   学士
学历
堪萨斯州立大学 --博士研究生

明尼苏达大学  --硕士研究生

学位
堪萨斯州立大学  --博士学位

 

工作经历

 

工作简历
2018-01~现在, 中国科学院大学, 特聘教授、博导
2002-08~现在, 中国科学院遗传与发育生物学研究所, 研究员、博导、创新研究组长
2000-03~2003-03,美国辛辛拉提大学医学院(UC), 助理教授
1998-11~2002-08,中国科学院遗传研究所, 研究员、 遗传室主任
1997-08~1997-11,石河子大学, 校长助理
1997-07~2000-03,美国伊利诺依大学(UIUC), 助理教授
1991-07~1997-07,伊利诺依大学, 博士后
1982-08~1985-09,石河子大学, 助教
社会兼职
2018-01-01-今,中国人才研究会经济人才专业委员会, 主任委员
2017-12-01-今,国家知识产权局专利审查, 评审专家
2015-10-01-今,中国医师协会腔内血管琳巴疾病专委会, 副主任委员
2015-01-01-今,中国实验动物学会专家委员会, 主任委员
2013-08-01-今,中国自然辩证法研究会科技哲学专业委员会, 常务理事
2013-02-01-今,新西兰梅西大学, 荣誉教授
2013-01-01-今,新西兰国家发育生物学研究中心(Gravida), 国际委员

教授课程

遗传发育学系列讲座
“百人学者论坛”系列讲座
分子遗传学
遗传与发育学前沿进展讲座

专利与奖励

   
奖励信息
(1) 新疆维吾尔自治区科技进步奖, 一等奖, 省级, 2016
(2) 享受国务院颁发政府特殊津贴专家, 国家级, 2009
(3) 新疆建设兵团科技进步奖, 一等奖, 省级, 2007
(4) 人事部等 7 部委新世纪“百千万”人才工程国家级人选, 部委级, 2004
(5) 国家杰出青年基金, 国家级, 2001
(6) 中国科学院“****”入选者, 其他, 1998
专利成果
( 1 ) SHON作为癌症预后生物标志物并预测癌症内分泌治疗的疗效, 实用新型, 2016, 第 1 作者, 专利号: 2013800639470

出版信息

   
发表论文

(1) Network-Based Functional Prediction Augments Genetic Association To Predict Candidate Genes for Histamine Hypersensitivity in Mice, G3, 2019-12, 第 6 作者
(2) SHON expression predicts response and relapse risk of breast cancer patients after anthracycline-based combination chemotherapy or tamoxifen treatment, Br J Cancer, 2019, 第 9 作者
(3) Discovery of a highly divergent hepadnavirus in shrews from China, Virology, 2019, 通讯作者
(4) Human Papillomavirus 16 oncoprotein E7 retards mitotic progression by blocking Mps1-MAP4 signaling cascade, Oncogene, 2019, 通讯作者
(5) A high-density BAC physical map covering the entire MHC region of addax antelope genome, BMC Genomics, 2019, 通讯作者
(6) Reticulocalbin 3 Deficiency in Alveolar Epithelium Exacerbated Bleomycin-induced Pulmonary Fibrosis, Am J Respir Cell Mol Biol, 2018, 通讯作者
(7) Extensive diversity and evolution of hepadnaviruses in bats in China, Virology, 2017, 第 10 作者
(8) Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma, Oncotarget, 2017, 通讯作者
(9) Mps1 kinase regulates tumor cell viability via its novel role in mitochondria, Cell Death Dis, 2016, 通讯作者
(10) A Preliminary Study on RCN3 Protein Expression in Non-small Cell Lung Cancer, Clin Lab, 2016, 通讯作者
(11) Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption, Am J Respir Cell Mol Biol, 2016, 通讯作者
(12) Spina bifida in fetus is associated with an altered pattern of DNA methylation in placenta, J Hum Genet, 2016, 通讯作者
(13) A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphase, BMC Cell Biol, 2015, 第 7 作者
(14) SHON is a novel estrogen-regulated oncogene in mammary carcinoma that predicts patient response to endocrine therapy, Cancer Res, 2014, 第 10 作者
(15) Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy, BiochemBiophys Res Commun, 2014, 第 10 作者
(16) Handmade cloned transgenic sheep rich in omega-3 Fatty acids, PLoS One, 2013, 通讯作者
(17) Genetic Evidence of an East Asian Origin and Paleolithic Northward Migration of Y-chromosome Haplogroup N, PLoS One, 2013, 第 6 作者
(18) Trop2 regulates the proliferation and differentiation of murine compact-bone derived MSCs, Int J Oncol, 2013, 通讯作者
(19) UV-C irradiation delays mitotic progression by recruiting Mps1 to kinetochores, Cell Cycle, 2013, 第 10 作者
(20) A physical map of a BAC clone contig covering the entire autosome insertion between ovine MHC Class IIa and IIb, BMC Genomics, 2012, 通讯作者
(21) Handmade cloned transgenic piglets expressing the nematode fat-1 gene, Cell Reprogram, 2012, 通讯作者
(22) Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2, BMC Cancer, 2012, 通讯作者
(23) Identification of sheep ovary genes potentially associated with off-season reproduction, J Genet Genomics, 2012, 通讯作者
(24) Two LXXLL motifs in the N terminus of Mps1 are required for Mps1 nuclear import during G(2)/M transition and sustained spindle checkpoint responses, Cell Cycle, 2011, 第 5 作者
(25) Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population, Arthritis Research and Therapy , 2011, 通讯作者
(26) Extended Y-chromosome investigation suggests post-Glacial migrations of modern humans into East Asia via the northern route, Mol Biol Evol , 2011, 通讯作者
(27) Closing a gap in the physical map of the ovine major histocompatibility complex,  Animal Genetics, 2011, 通讯作者
(28) Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia, J Hum Genet, 2010, 第 6 作者
(29) Construction of a bacterial artificial chromosome library for the Rongchang pig breed and its use for the identification of genes involved in intramuscular fat deposition, BiochemBiophys Res Commun, 2010, 通讯作者
(30) A complete DNA sequence map of the ovine Major Histocompatibility Complex. , BMC Genomics., 2010, 通讯作者
(31) The ADH1B Arg47His polymorphism in east Asian populations and expansion of rice domestication in history. , BMC Evol Bio, 2010, 通讯作者
(32) Cloning and Characterization of a Calcium-Activated Chloride Channel in Rat Uterus, Biol Reprod, 2009, 通讯作者
(33) Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia, Am J Hum Genet, 2009, 第 10 作者
(34) Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations, BMC Biol, 2008, 第 9 作者
(35) A murine model for human immune thrombocytopenic purpura and comparative analysis of multiple gene expression in bone marrow and spleen, J Genet Genomics, 2008, 通讯作者
(36) Structures of a HPV-E6 polypeptide bound to MAGUK proteins: Mechanisms of targeting tumor suppressors by a high-risk HPV oncoprotein, J. Virology, 2007, 第 3 作者
(37) Microsatellite genotyping for four expected inbred mouse strains from KM mice, J Genet Genomics, 2007, 通讯作者
(38) A BAC-based physical map of Ovine Major Histocompatibility Complex (MHC), Genomics, 2006, 通讯作者
(39) Structure of the Epstein-Barr virus major envelope glycoprotein., Nat Struct Mol Biol., 2006, 第 5 作者
(40) Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli, Protein Expres and Purif, 2003, 第 2 作者
(41) Glucocorticoids Induce Cytosolic Phospholipase A (2) and Prostaglandin H Synthase Type 2 But Not Microsomal Prostaglandin E Synthase (PGES) and Cytosolic PGES Expression in Cultured Primary Human Amnion Cells, J Clin Endocrinol Metab, 2003, 第 2 作者
(42) Sex-Specific Quantitative Trait Loci Govern Susceptibility to Theiler’s Murine Encephalomyelitis Virus-Induced Demyelination, Genetics, 2003, 第 6 作者
(43) Identification of Bphs, an autoimmune diseases locus, as histamine receptor H1, Science, 2002, 第 1 作者
(44) Genetic Control of Immunoregulation, Loss of Peripheral Tolerance, and Autoimmune Ovarian Dysgenesis after Day Three Thymectomy in Mice, J Immunol, 2002, 第 2 作者
(45) Development and mapping of microsatellites from a microdissected BTA 11-specific DNA library, Animal Genetics, 2001, 第 4 作者
(46) Phylogenetic relationships of Cheju horses to other horse breeds as determined by mtDNA D-loop sequence polymorphism, Animal Genetics, 1999, 第 5 作者
(47) Physical mapping of the autoimmune disease susceptibility locus, Bphs: Co-localization with a cluster of genes from the TNF receptor superfamily on mouse chromosome 6, Mamm Gemone, 1999, 第 5 作者
(48) Sequence polymorphisms in the chemokines scya1 (TCA-3), scya2 (Monocyte chemoattractant protein (MCP)-1), and scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic Remitting/Nonrelapsing experimental allergic encephalomyelitis., J Immunol, 1999, 第 3 作者
(49) Standardization and conversion of marker polymorphism measures, AnimBiotecol, 1999, 第 8 作者
(50) Chlorophyll loses in the sorghum susceptible to greengubs (Schizaphisgraminum), J Kansas EntSoc, 1999, 第 1 作者
(51) Report of the first workshop on the genetic map of bovine chromosome 1, Animal Genetics, 1998, 第 10 作者
(52) Comparative analysis of 82 expressed sequence tags from a bovine ovary cDNA library, Mamm Genome, 1998, 第 1 作者
(53) Using PCR to distinguish Diaporthephaseolorun and Phomopsislongicolla from other soybean fungal pathogens and to detect them in soybean tissues, Plant Disease, 1997, 第 5 作者
(54) A male linkage map of the cattle (Bostaurus) genome, J Heredity, 1996, 第 1 作者
(55) Report on the first workshop on the genetic map of bovine chromosome 23, Animal Genetics, 1996, 第 10 作者
(56) Isolation and characterization of 45 polymorphic microsatellites from the bovine genome, Animal Genetics, 1996, 第 1 作者
(57) A panel of bovine, ovine and caprine microsatellites, Animal Genetics, 1995, 第 5 作者
(58) Genetic mapping of the LMP2 proteasome subunit gene to the BoLA class IIb region, Immunogenetics, 1995, 第 5 作者
(59) Black Swallowtail (Papilliopolyxenes) alleles encode Cytochrome P-450s that selectively metabolize linear furanocumarins, Arch Biochem Biophysics, 1994, 第 1 作者
(60) Host seeking behavior of Eriborusterebrans(Hymenoptera: Ichneumonidae) toward the European corn borer (Ostrinianubilalis), and the role of chemical stimuli, Ann EntSocAmer, 1992, 第 1 作者
(61) Genome size and organization in an aphid (Schizaphisgraminum), J Insect Physiol, 1992, 第 1 作者
(62) Detection of pectinesterase and polygalacturonase from salivary secretions of living greenbugs (Schizaphisgraminum) (Homoptera: Aphididae), J Insect Physiol, 1990, 第 1 作者

 
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